سنتز 1، 3، 5، 7-تترا استیل-1، 3، 5، 7-تترا آزاسیکلواکتان (TAT) از طریق استیلدار کردن 3، 7-دیاستیل-1، 3، 5، 7-تترا آزا بیسیکلو-[3.3.1]-نونان (DAPT)
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Abstract:
In this study, a novel method to synthesis of 1,3,5,7-tetraacetyl octahydro-1,3,5,7-tetraazocine or 1,3,5,7-tetraacetyl-1,3,5,7-tetraazacyclooctane (TAT) was used through acetolysis of 3,7-diacetyl-1,3,5,7-tetraazabicyclo-[3.3.1]nonane (DAPT) with acetic anhydride in the presence of sodium acetate as catalyst. Optimized reaction conditions were obtained by changing temperature, time and starting material concentrations. The advantages of this method are: elimination of byproducts such as 1,3,5-triacetyl-1,3,5-triazacyclohexane (TRAT), recoverable waste streams, easy process and high yield. Also, there is no need for further purification of the product as the reaction leads to the formation of the pure product.
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volume 12 issue 3
pages 179- 186
publication date 2017-12
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